Oxymetholone belongs to a group of anabolic-androgenic steroid with one the most harmful effects. This substance is directly associated with liver cancer. It can cause liver failure, initially manifested in elevated values, but later the prolonged use of this substance leads to liver damage. Among the estrogenic side effects is the emergence of gynecomastia. The high retention of water and salt increases the blood pressure. Oxymetholone has a significant impact on reducing the production of testosterone. It also increases the number of red blood cells. Part of the active substance is converted to dihydrotestosterone (DHT), so some individuals may experience severe hair loss and acne. Other side effects may be a headache, nausea, stomach pain, vomiting, insomnia, and diarrhea. Insufficient intake of carbohydrates may induce a state of hypoglycemia. A greater level of aggression is attributed to increased levels of androgens and rises at a simultaneous application of large doses of testosterone. Leads to changes in the values of HDL (good) and LDL (bad) cholesterol. Gains from the substance tend to disappear fairly quickly after discontinuation.
It is one of the few anabolic-androgenic steroids, which abused dose is significantly lower than the so-called therapeutic dose, commonly used in the treatment process. The package leaflet usually indicates a therapeutic dosage of 1-5 mg per 1 kg body weight. A suggestion is that athletes due to the high toxicity of the substance opt for the optimal dose to be 50-100 mg per day. Its half-life (biological half-life) is 8-9 hours. Therefore, only short-term abuse of this substance should be considered (maximum 3-5 weeks) because the receptors responsible to react to this substances do that only for a short period. However, as oxymetholone causes a significant reduction in the level of natural androgens, after discontinuation the vast majority observe gains are lost. That is why quality PCT is a necessity.
Athletes take oxymetholone primarily as a „starter” substance at the beginning of the injection cycle, which effect is slow (e.g. with testosterone, nandrolone, methenolone, boldenone). Separate use of oxymetholone is not relevant, as the results are hardly sustainable. Studies show that the substance stays in the urine for about 50-60 days.