It is highly toxic to the liver, risk of acne, risk of gynecomastia
For physique or performance-enhancing purposes, the drug is also used intermittently, with cycles usually lasting between 6 and 8 weeks in length followed by 6-8 weeks off. Although a low dose of 5 mg daily may be effective for improving performance, athletes typically take much higher amounts. A daily dosage of 15-30 mg is most common and typically produces very dramatic results.
The effective dose of yohimbine is 0.2 mg/kg body weight. Thanks to fat burning and stimulating effects of yohimbine are convenient to take the dose at morning.